Emily J Owen, Rachel A Heylen, Kyle Stewart, Paul G Winyard, A Toby A Jenkins
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引用次数: 0
摘要
本综述讨论了目前对尿失禁相关皮炎 (IAD) 预防和治疗的认识。其中强调了针对特定粪便/尿液刺激物采取预防措施的必要性,包括尿素酶抑制剂的作用。目前还没有国际和临床公认的方法来诊断 IAD 并对其严重程度进行分类。目前,诊断主要依靠肉眼观察;评估皮肤屏障功能的非侵入性技术可以消除主观性,特别是对于肤色较深的人。阻抗光谱仪是一种非侵入性技术,可用于监测皮肤屏障功能,为目测评估提供支持。我们对六项使用阻抗评估皮炎的研究(2003-2021 年)进行了回顾;在每项研究中,发炎皮肤与健康皮肤都能区分开来。这表明,阻抗光谱法可用于诊断早期 IAD,从而有可能实现早期干预。最后,作者介绍了他们利用阻抗能谱对体内 IAD 模型中脲酶在皮肤破坏中的作用进行研究的初步发现。
Detecting and monitoring incontinence associated dermatitis: Does impedance spectroscopy have a part to play?
In this review, current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD) is discussed. The need for preventative measures which target specific faecal/urinary irritants is highlighted, including the role of urease inhibitors. There is no existing internationally and clinically accepted method to diagnose and categorise the severity of IAD. Diagnosis currently relies on visual inspection; non-invasive techniques to assess skin barrier function could remove subjectiveness, particularly in darker skin tones. Impedance spectroscopy is a non-invasive technique which can be used to monitor skin barrier function, supporting visual assessments. Six studies (2003-2021) which used impedance to assess dermatitis were reviewed; inflamed skin was distinguishable from healthy skin in each case. This suggests that impedance spectroscopy could be useful in diagnosis early-stage IAD, potentially enabling earlier intervention. Finally, the authors present their initial findings on the role of urease in skin breakdown in an in vivo IAD model, using impedance spectroscopy.
期刊介绍:
The Journal of Engineering in Medicine is an interdisciplinary journal encompassing all aspects of engineering in medicine. The Journal is a vital tool for maintaining an understanding of the newest techniques and research in medical engineering.