从评估危险因素到了解、预防和治疗心血管疾病:一个紧迫的旅程。

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Discovery medicine Pub Date : 2022-11-01

António Heitor Reis

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引用次数: 0

摘要

在大量已发表的文献的基础上，我们在之前文章中已经提出的框架中扩展了对心血管疾病的理解。在这种情况下，解释了血管病变的一些独特特征。载脂蛋白apoB100的作用的基本原理提出。有假说认为，冠状动脉痉挛和心肌细胞死亡的发生背后，是K∧ATP∧通道及其受血液pH的控制。最后，在提出的框架内解释了主要的心血管风险。

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From Assessing Risk Factors to Understanding, Preventing, and Treating Cardiovascular Diseases: an Urgent Journey.

Based on the abundant published literature, here we expand the understanding of cardiovascular diseases in a framework already presented in previous articles. In this context, some unique distinguishing features of vascular lesions are explained. A rationale for the role of apolipoprotein apoB100 is presented. It is hypothesized that K⊂ATP⊂ channels and their control by blood pH are behind the development of coronary artery spasm and cardiomyocyte death. Finally, the main cardiovascular risks are explained within the proposed framework.

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.