子宫内给药免疫活性人细胞产生特异性免疫耐受的实验。

Annales immunologiae Hungaricae Pub Date : 1975-01-01
E Osz, L Réthy
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引用次数: 0

摘要

由于在怀孕第16天子宫内注射了活的人类白细胞,因此不可能研究这窝婴儿,因为它在分娩后立即成为同类相食的受害者。给予声崩解白细胞抗原后,健康新生儿被丢弃。以这种方式处理的小鼠在2天前给予活的人类白细胞,没有产生GVH反应,可以确定体重减轻,但与对照组相比,发生了相当多的死亡。讨论了利用细胞嵌合体进一步研究抗人抗胸腺细胞血清的可能性。
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Experiments for producing specific immunological tolerance by intrauterinely administered immunocompetent human cells.

As a consequence of living human leukocytes administered intrauterinely on the 16th day of pregnancy, it was not possible to study the litter since it fell victim to cannibalism immediately after delivery. After the administration of sonically disintegrate leukocyte antigen healthy newborns were dropped. Living human leukocytes administered before the age of 2 day to mice treated in this way, produced no GVH reaction ascertainable with loss of weight but a considerable number of deaths occurred in comparison to the control. Further possibilities of studying the anti-human anti-thymocyte serum by means of cell chimeras are discussed.

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