The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions.

INTRODUCTION............ 449 PROPERTIES OF PEPTIDE ANTIBIOTICS 449 FORMATION OF ANTIBIOTICS IN RELATION TO GROWTH ...... ............ 450 CELL-FREE SYNTHESIS OF PEPTIDE ANTIBIOTICS ...... .................. 451 ENZYMATIC SYNTHESIS OF GRAMICIDIN S ........ ......................... 451 ENZYMATIC FORMATION OF TYROCIDINE ........ ......................... 453 LINEAR GRAMICIDINS ...................... ................................. 456 BACITRACINS ................................................................ 457 EDEINE...................................................................... 458 MYCOBACILLIN ................. ............................................ 459 POLYMYXIN AND COLISTIN ............... .................................. 460 SPECIFICITY OF INCORPORATION ........... ............................... 461 RACEMIZATION AND THE SYNTHESIS OF D-AMINO ACIDS.................. 463 MUTANT STUDIES .......................................................... 464 POSSIBLE FUNCTIONS OF PEPTIDE ANTIBIOTICS IN THE PRODUCING ORGANISM .............................................................. 465 CONCLUDING REMARKS ................... .................................. 468 ADDENDUM IN PROOF .................... .................................. 469 LITERATURE CITED......................................................... 469