{"title":"氧化二丙基亚硝胺对小鼠的致癌作用。一、二丙基亚硝胺和甲基丙基亚硝胺。","authors":"S Dickhaus, G Reznik, U Green, M Ketkar","doi":"10.1007/BF00284299","DOIUrl":null,"url":null,"abstract":"<p><p>Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration. The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi. Treatment with both substances additionally resulted in vascular neoplasms of the liver, while DPN only caused tumors in the pharynx, esophagus and forestomach.</p>","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"90 3","pages":"253-8"},"PeriodicalIF":0.0000,"publicationDate":"1977-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00284299","citationCount":"4","resultStr":"{\"title\":\"The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine.\",\"authors\":\"S Dickhaus, G Reznik, U Green, M Ketkar\",\"doi\":\"10.1007/BF00284299\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration. The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi. Treatment with both substances additionally resulted in vascular neoplasms of the liver, while DPN only caused tumors in the pharynx, esophagus and forestomach.</p>\",\"PeriodicalId\":76850,\"journal\":{\"name\":\"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology\",\"volume\":\"90 3\",\"pages\":\"253-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF00284299\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF00284299\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF00284299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine.
Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration. The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi. Treatment with both substances additionally resulted in vascular neoplasms of the liver, while DPN only caused tumors in the pharynx, esophagus and forestomach.
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