{"title":"[对二甲氨基偶氮苯与大鼠肝脏染色质和非组蛋白的相互作用(作者译)]。","authors":"J So-nenbichler, F Reichhart","doi":"10.1007/BF00305972","DOIUrl":null,"url":null,"abstract":"<p><p>The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.</p>","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"91 1","pages":"55-61"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00305972","citationCount":"0","resultStr":"{\"title\":\"[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].\",\"authors\":\"J So-nenbichler, F Reichhart\",\"doi\":\"10.1007/BF00305972\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.</p>\",\"PeriodicalId\":76850,\"journal\":{\"name\":\"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology\",\"volume\":\"91 1\",\"pages\":\"55-61\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-01-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF00305972\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF00305972\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF00305972","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].
The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.
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