黄酮醇2-(3,4,5-二甲氧基苯基)-3-羟基- 4h -铬-4- on的合成及抗氧化抗癌活性研究

Jurnal Natur Indonesia Pub Date : 2019-10-30 DOI:10.31258/jnat.17.2.16-24

Muhamad Rokim, A. Zamri, H. Y. Teruna

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引用次数: 0

摘要

在碱性条件(KOH)下合成了2′-羟基卡酮的2-(3,4,5-二甲氧基苯基)-3-羟基-4-铬-4-on)衍生物黄酮醇。通过紫外、红外光谱、核磁共振、质谱等光谱数据对化合物的结构进行了表征。DPPH法测定其抗氧化活性，MTS法测定其抗癌活性，结果表明黄酮醇2′-羟卡酮衍生物具有抗氧化和抗癌活性，IC50值<1000µg / mL。

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Synthesis, Test of Antioxidant and Anticancer Activities Flavonol 2- (3,4,5-Dimethoxyphenyli) -3-Hydroxy-4H-Chromen-4-On

Flavonols 2-(3,4,5-dimethoxyphenyli)-3-hydroxy-4h-chromen-4-on) derivatives of 2'-hydroxycalone have been synthesized under basic condition (KOH). The structures of all compounds were characterized based on the interpretation of spectroscopic data including UV, FTIR, NMR and HRMS. Antioxidant activity was evaluated using the DPPH assay and anticancer activity was evaluated using the MTS assay which showed that the flavonol 2'-hydroxycalone derivative was potentially active as antioxidants and anticancer with IC50 values <1000 µg / mL.

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Jurnal Natur Indonesia

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