[肾上腺切除术、氢化可的松和ACTH对兔组织中游离氨基酸含量的影响]。

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-11-01
T M Mishunina, A Ia Mestechkina, V F Lisak
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引用次数: 0

摘要

肾上腺切除术伴随着肌肉和血浆中游离氨基酸含量的减少和肝脏中某些氨基酸含量的增加。肾上腺切除动物单次注射氢化可的松可增加肌肉中氨基酸的含量并降低其在肝脏中的总含量;单次注射ACTH降低肝脏和血浆中氨基酸的总含量氢化可的松“替代疗法”实质上是增加肝脏、肌肉和血浆中氨基酸的含量。在实验条件下,脑组织中氨基酸含量的变化最小。
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[Content of free amino acids in rabbit tissues as affected by adrenalectomy and administration of hydrocortisone and ACTH].

Adrenalectomy is accompanied by a decreased content of free amino acids in muscules and blood plasma by an increased content of certain amino acids in the liver. A single injection of hydrocortisone to adrenalectomized animals increases the content of amino acids in muscles and lowers their total content in the liver; a single injection of ACTH lowers the total content of amino acids in the liver and blood plasma "Substitutive therapy" by hydrocortisone essentially increases the content of amino acids in the liver, muscles and blood plasma. Under conditions of the experiment the least changes in the content of amino acids were found in the brain tissue.

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