Significance of the multifunctional protein C system research in the treatment of patients with indirect anticoagulants (literature review)

The multifunctional protein C system regulates both hemostasis and the immune system in response to vascular and inflammatory damage, inhibits thrombinogenesis at an early stage of clotting. A decrease in protein C levels in clinical practice may be associated with vitamin K deficiency, as well as with coumarin therapy. Prolonged use of indirect anticoagulants may be accompanied by a decrease in protein C levels and contribute to the development of rebound thrombosis and thromboembolism. The depth of violations of the protein C system indicates the activation of the microthrombosis process and may affect the outcome of treatment of surgical patients.