新型冠状病毒感染后鼻-脑型黏液菌病的综合治疗组织

J. Abdullozoda, G. M. Khojamurаdov, Khizmatullah A. Shamszoda, M. Khamidov, R. Tursunov
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摘要

目的:探索新型冠状病毒感染后鼻-脑型毛霉病综合治疗的最佳方案。材料和方法:对来自塔吉克斯坦共和国不同地区的48例被诊断为鼻脑型毛霉病的患者的治疗数据进行了仔细分析。结果与讨论:分析发现,感染COVID-19的患者(n=12;0.9%),并且有现有的健康状况,在感染后大约1-3个月的早期阶段经历了神经血管功能不全。这种情况表面上是由病毒直接破坏血脑屏障、高凝和随后的神经血管并发症引起的。还注意到,这些患者在治疗期间使用了第五代抗生素和糖皮质激素。结论:研究结果表明,在covid后时期出现鼻-脑形式的毛霉病,特别是在同时存在健康状况的患者中,可能与免疫力减弱和免疫缺陷有关。这些通常是由于长期不受管制地使用抗生素和糖皮质激素引起的,从而导致致病性真菌和机会性真菌的增加。根据这些调查结果,建议这些病人到专门的医疗机构接受适当的治疗。
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Organization of complex treatment of the rhinocerebral form of mucormicosis in the post-covid period
Aim: To develop an optimal variant of complex treatment of the rhinocerebral form of mucormycosis in the postCOVID period.Materials and Methods: Treatment data from 48 patients diagnosed with the rhinocerebral form of mucormycosis, sourced from various regions of the Republic of Tajikistan, was scrutinized for this analysis.Results and Discussion: The analysis revealed that patients who had contracted COVID-19 (n=12; 0.9%) and had existing health conditions, experienced the onset of neurovascular insufficiency in the early stages of the post-COVID period, roughly 1-3 months subsequent to the infection. This condition was ostensibly triggered by the direct viral disruption of the blood-brain barrier, hypercoagulation, and ensuing neurovascular complications. It was also noted that these patients had been administered fifth-generation antibiotics and glucocorticosteroids during their treatment.Conclusion: The study findings suggest that the emergence of the rhinocerebral form of mucormycosis in the postCOVID period, especially in patients with concurrent health conditions, could be linked to weakened immunity and immunodeficiency. These are often induced by the prolonged, unregulated use of antibiotics and glucocorticosteroids, consequently leading to an increase in pathogenic and opportunistic fungi. In light of these findings, it is recommended that such patients be admitted to specialized medical institutions for appropriate treatment.
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