纳米药物治疗癌症是否可能个人化?透视及安全设计

M. Durán, Â. C. Luzo, N. Durán, W. Fávaro
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引用次数: 0

摘要

化疗在挽救和延长生命方面的重要性已被清楚地证明,相反,在一般情况下,它会对许多病人产生不良的副作用,对某些癌症完全无效。个性化的癌症治疗方法是针对个体癌细胞的特定分子特征,以提高治愈率,减少副作用和安全设计为目标。从文献中可以看出,将已经发表的与不同癌症研究相关的丰富分子信息(如突变和基因表达概述)与相关的治疗策略相结合是绝对重要的。值得注意的是,纳米技术是一种众所周知的技术,是实现这一目的的强大工具。本文将介绍与纳米医学相关的重要领域,可能会允许个性化的癌症治疗策略,并重点介绍个性化纳米医学的最新进展,未来的方向和相关的挑战,该领域的前景和可能的解决方案,以及对风险的关注。
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Is it Possible to Personalize the Nanomedicine in Cancer? Perspectives and Safety Designs
The importance of chemotherapy has been clearly demonstrated to save and prolong lives, on contrary, in general, it can cause adverse side effects in many patients and totally inefficient in certain cancers. The personalized approaches to cancer therapy appears as one that can target specific molecular characteristics of an individual’s cancer cells, with the object to enhance cure rates, minimizing side effects and a safety design. As it is possible to see from the literature, it is absolutely important to integrate the copious molecular information already published related to different cancer´s studies (e.g., mutational and gene expression outlines) with relevant therapeutic strategies. Important to notice that nanotechnology is a long known technique that is a powerful tool for this kind of purpose. This review will describe important areas related to nano-medicine and probably it may permit personalized strategies to cancer treatment, and highlight advances in the State of Art personalized nano-medicine with future directions and related challenges, prospect and possible solutions for this area and the concern with risks is another point that will be discussed.
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