{"title":"纳米药物治疗癌症是否可能个人化?透视及安全设计","authors":"M. Durán, Â. C. Luzo, N. Durán, W. Fávaro","doi":"10.2139/ssrn.3622558","DOIUrl":null,"url":null,"abstract":"The importance of chemotherapy has been clearly demonstrated to save and prolong lives, on contrary, in general, it can cause adverse side effects in many patients and totally inefficient in certain cancers. The personalized approaches to cancer therapy appears as one that can target specific molecular characteristics of an individual’s cancer cells, with the object to enhance cure rates, minimizing side effects and a safety design. As it is possible to see from the literature, it is absolutely important to integrate the copious molecular information already published related to different cancer´s studies (e.g., mutational and gene expression outlines) with relevant therapeutic strategies. Important to notice that nanotechnology is a long known technique that is a powerful tool for this kind of purpose. This review will describe important areas related to nano-medicine and probably it may permit personalized strategies to cancer treatment, and highlight advances in the State of Art personalized nano-medicine with future directions and related challenges, prospect and possible solutions for this area and the concern with risks is another point that will be discussed.","PeriodicalId":119595,"journal":{"name":"Nanomaterials eJournal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is it Possible to Personalize the Nanomedicine in Cancer? Perspectives and Safety Designs\",\"authors\":\"M. Durán, Â. C. Luzo, N. Durán, W. Fávaro\",\"doi\":\"10.2139/ssrn.3622558\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The importance of chemotherapy has been clearly demonstrated to save and prolong lives, on contrary, in general, it can cause adverse side effects in many patients and totally inefficient in certain cancers. The personalized approaches to cancer therapy appears as one that can target specific molecular characteristics of an individual’s cancer cells, with the object to enhance cure rates, minimizing side effects and a safety design. As it is possible to see from the literature, it is absolutely important to integrate the copious molecular information already published related to different cancer´s studies (e.g., mutational and gene expression outlines) with relevant therapeutic strategies. Important to notice that nanotechnology is a long known technique that is a powerful tool for this kind of purpose. This review will describe important areas related to nano-medicine and probably it may permit personalized strategies to cancer treatment, and highlight advances in the State of Art personalized nano-medicine with future directions and related challenges, prospect and possible solutions for this area and the concern with risks is another point that will be discussed.\",\"PeriodicalId\":119595,\"journal\":{\"name\":\"Nanomaterials eJournal\",\"volume\":\"9 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomaterials eJournal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2139/ssrn.3622558\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomaterials eJournal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2139/ssrn.3622558","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is it Possible to Personalize the Nanomedicine in Cancer? Perspectives and Safety Designs
The importance of chemotherapy has been clearly demonstrated to save and prolong lives, on contrary, in general, it can cause adverse side effects in many patients and totally inefficient in certain cancers. The personalized approaches to cancer therapy appears as one that can target specific molecular characteristics of an individual’s cancer cells, with the object to enhance cure rates, minimizing side effects and a safety design. As it is possible to see from the literature, it is absolutely important to integrate the copious molecular information already published related to different cancer´s studies (e.g., mutational and gene expression outlines) with relevant therapeutic strategies. Important to notice that nanotechnology is a long known technique that is a powerful tool for this kind of purpose. This review will describe important areas related to nano-medicine and probably it may permit personalized strategies to cancer treatment, and highlight advances in the State of Art personalized nano-medicine with future directions and related challenges, prospect and possible solutions for this area and the concern with risks is another point that will be discussed.