Kenei Matsudaira, Thanh-Vinh Nguyen, K. H. Shoji, T. Tsukagoshi, T. Takahata, I. Shimoyama
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Mems force sensor array for evaluating the contractility of IPS cell-derived cardiomyocytes
We report a force sensor array that can measure iPS cell-derived cardiomyocytes (iPS-CMs) contractility with high sensitivity and high temporal resolution. The fabricated device has six piezoresistive cantilevers whose sensitivities were higher than 9.1 × 10−5 nN−1. Using the device, we measured the contraction force of an iPS-CMs layer. As a result, contractile forces ranging from 1 to 12 nN were measured.
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