A clinical case of the use of a combination of cimicoxib and cyclophosphamide in metronomic mode in neoadjuvant therapy of complex breast carcinoma of a dog

The results of the use of a combination of cimicoxib and cyclophosphamide, in metronomic mode, in neoadjuvant therapy of complex breast carcinoma in dogs are presented. This treatment regimen allowed to achieve stabilization of the process, the volume of the tumor decreased by 60.77% of the indicators of the first day. The regression was 39.23%. According to the results of hematological blood examination, by the 90th day of therapy, the number of leukocytes decreased by 75.96%, lymphocytes by 79.67% and granulocytes by 75.64%, to reference values. The number of red blood cells and the level of hemoglobin increased by 49.57% and 53.98%, respectively. There was an increase in the amount of hematocrit by 52.35% compared to the values of the first day before therapy. Biochemical parameters of blood serum by the end of drug therapy were within the reference values. There were no signs of hematological and general toxicity, according to the WHO scale, requiring corrective therapy, dose reduction or withdrawal of drugs.