ADM (Dermacell)治疗手部肥厚性瘢痕(HSs)后挛缩性瘢痕

Spyridon Maragkos, Giampietro Bertasi, Mariana Peroni
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引用次数: 0

摘要

在皮肤损伤或伤口后,增生性疤痕可以出现在皮肤的任何地方。原因尚不完全清楚,其结果是多余胶原蛋白的异常产生和弹性蛋白的减少,从而导致这些不受欢迎的厚,凸起的僵硬疤痕。有时会进行手术切除疤痕或重新定位疤痕上的张力线。通常,当其他治疗方案失败时,会考虑手术。真皮细胞是人类脱细胞基质(hADM),用于软组织修复的补充支持和覆盖。它起到了ECM的作用。细胞外基质(ECM)分子在真皮中的表达和增殖,由一系列生长因子和细胞因子介导,是伤口修复的基本要素。
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Treatment of retractile scar after a hypetrophic scar (HSs) in the hand with ADM (Dermacell)
Hypertrophic scars can occur anywhere on skin after a skin injury or wound. The reason is not fully understood, the result is the abnormal production of extra collagen and a decrease in elastin, which lead to these undesirable thick, raised stiff scars. Sometimes surgery is performed to cut out the scar or redirect the lines of tension on the scar. Usually, surgery is considered when other treatment options have failed. Dermacell is human acellular matrix (hADM) that is intended for supplemental support and covering for soft tissue repair. It acts as ECM. The expression and proliferation of extracellular matrix (ECM) molecules in the dermis, mediated by a range of growth factors and cytokines, is a fundamental element of wound repair.
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