{"title":"[四氯甲烷对多环烃作用下大鼠肝脏线粒体α -酮戊二酸脱氢酶和琥珀酸脱氢酶活性的影响]。","authors":"Iu I Gubs'kiĭ, T P Pradiĭ","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The activity of the mitochondria internal membrane ensymes alpha-ketoglutarate dehydrogenase and succinate dehydrogenase was studied after rats poisoning with CCl4. It is established that the activity of these enzymes lowers considerably under effect of CCl4, which is more pronounced for alpha-ketoglutarate dehydrogenase. The pretreatment of animals with inducer of microsomal oxidases intensifies the damaging effect of CCl4 on the internal membranes of mitochondria and decreases the LD50 value for CCL4. Administration of actinomycin D simultaneously with polycyclic hydrocarbons prevents intensification of the CCl4 hepatotoxic effect caused by 3-methylcholanthrene and dibenz (a, h) anthracene.</p>","PeriodicalId":23396,"journal":{"name":"Ukrains'kyi biokhimichnyi zhurnal","volume":"49 4","pages":"26-30"},"PeriodicalIF":0.0000,"publicationDate":"1977-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of tetrachloromethane on alpha-ketoglutarate dehydrogenase and succinate dehydrogenase activity in mitochondria of rat liver under conditions of administration of polycyclic hydrocarbons].\",\"authors\":\"Iu I Gubs'kiĭ, T P Pradiĭ\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The activity of the mitochondria internal membrane ensymes alpha-ketoglutarate dehydrogenase and succinate dehydrogenase was studied after rats poisoning with CCl4. It is established that the activity of these enzymes lowers considerably under effect of CCl4, which is more pronounced for alpha-ketoglutarate dehydrogenase. The pretreatment of animals with inducer of microsomal oxidases intensifies the damaging effect of CCl4 on the internal membranes of mitochondria and decreases the LD50 value for CCL4. Administration of actinomycin D simultaneously with polycyclic hydrocarbons prevents intensification of the CCl4 hepatotoxic effect caused by 3-methylcholanthrene and dibenz (a, h) anthracene.</p>\",\"PeriodicalId\":23396,\"journal\":{\"name\":\"Ukrains'kyi biokhimichnyi zhurnal\",\"volume\":\"49 4\",\"pages\":\"26-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ukrains'kyi biokhimichnyi zhurnal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukrains'kyi biokhimichnyi zhurnal","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Effect of tetrachloromethane on alpha-ketoglutarate dehydrogenase and succinate dehydrogenase activity in mitochondria of rat liver under conditions of administration of polycyclic hydrocarbons].
The activity of the mitochondria internal membrane ensymes alpha-ketoglutarate dehydrogenase and succinate dehydrogenase was studied after rats poisoning with CCl4. It is established that the activity of these enzymes lowers considerably under effect of CCl4, which is more pronounced for alpha-ketoglutarate dehydrogenase. The pretreatment of animals with inducer of microsomal oxidases intensifies the damaging effect of CCl4 on the internal membranes of mitochondria and decreases the LD50 value for CCL4. Administration of actinomycin D simultaneously with polycyclic hydrocarbons prevents intensification of the CCl4 hepatotoxic effect caused by 3-methylcholanthrene and dibenz (a, h) anthracene.
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