Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack
{"title":"犬肉瘤的IL-2扩增肿瘤浸润自然杀伤细胞具有很强的抗肿瘤细胞毒性","authors":"Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack","doi":"10.1136/jitc-2022-sitc2022.1016","DOIUrl":null,"url":null,"abstract":"Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.","PeriodicalId":398566,"journal":{"name":"Regular and Young Investigator Award Abstracts","volume":"2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1016 IL-2 expanded tumor infiltrated Natural Killer (TINK) cells from canine sarcomas possess potent anti-tumor cytotoxicity\",\"authors\":\"Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, A. Zhang, B. Séguin, Jeffrey C. Bryan, T. Fan, Jennifer Wu, S. Pollack\",\"doi\":\"10.1136/jitc-2022-sitc2022.1016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.\",\"PeriodicalId\":398566,\"journal\":{\"name\":\"Regular and Young Investigator Award Abstracts\",\"volume\":\"2 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Regular and Young Investigator Award Abstracts\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/jitc-2022-sitc2022.1016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regular and Young Investigator Award Abstracts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/jitc-2022-sitc2022.1016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Background Tumor infiltrating NK (TINK) cells are present and linked to prognosis in many solid tumors. 1 While these cells may have potent antitumor effector function, they are thought to be dysfunctional in the tumor microenvironment (TME). 2 Because it is difficult to culture potent TINKs from human tumors, relatively little is known about their interac-tions with various TME components or their potential for therapeutic applications. Here we report reproducible culture of highly potent TINKs from naturally occurring canine sarcomas for use in modeling the human TME.
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