COMPARISON POTENCY ASSAY METHODS AS PLAQUE FORMING UNIT (PFU) AND CELL CULTURE INFECTIOUS DOSE 50% (CCID50) OF THE CANDIDATE NATIONAL REFERENCE STANDARD MEASLES VACCINE

A comparative study of two methods (PFU and CCID50) for potencydetermination for the national standard candidate measles vaccine was organized atthe National Institute for Control of Vaccines and Biologicals (NICVB). Twomethods are performed on the groups of candidate National Reference Standardmeasles vaccine derived from AIK-C strain stored at different temperatures: -700C,40C/7 days, 370C/7 days. The results show that although there is a difference, strongcorrelation exists between the two methods CCID50 and PFU with R2=0,886, r =0,94, coefficient PFU/CCID50 = 1.28 equivalent to the ratio PFU: CCID50 = 1:0.78.