术后抗结核治疗引起的肝毒性

Bincy Charley, Rintu Mary Roy, S. Philip
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引用次数: 0

摘要

全球传染病相关死亡的最常见原因是结核病(TB),这是一种多系统疾病,具有广泛的表现和症状。约12%的肺外结核病例和所有结核病例的1-3%由腹部结核引起。长期以来,抗结核药物性肝损伤(ATLI)问题一直是结核病感染管理中的一个挑战,其重要性日益增加。减少ATLI发生的主要步骤是确定可能的肝毒性危险因素,并提供适当的基于体重的抗结核治疗(ATT)。本病例报告阐明了以体重为基础适当给药的重要性,特别是在患者术后体重明显减轻的情况下。
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Anti-tuberculosis treatment-induced hepatotoxicity in a post-operative setting
The most frequent cause of infectious disease-related mortality globally is tuberculosis (TB), a multisystemic disease with a wide range of presentations and symptoms. Around 12% of extrapulmonary TB cases and 1–3% of all TB cases are caused by abdominal TB. The issue of antituberculosis drug-induced liver injury (ATLI), which has long been a challenge in the management of TB infection, is one of increased significance. The major steps to reduce the occurrence of ATLI are to identify the possible risk factors of hepatotoxicity and to provide an appropriate weight-based anti-tuberculosis treatment (ATT). This case report clarifies the significance of appropriate weight-based dosing of ATT, particularly in a post-operative environment as evidenced in this instance where the patient experienced considerable post-operative weight loss.
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