{"title":"增强型参考导向装配","authors":"F. Cattonaro, A. Policriti, F. Vezzi","doi":"10.1109/BIBM.2010.5706540","DOIUrl":null,"url":null,"abstract":"Next Generation Sequencing has totally changed genomics: we are able to produce huge amounts of data at an incredible low cost if compared to Sanger sequencing. Despite this some old problems have become even more difficult, denovo assembly being on top of this list. In this paper we propose a novel method that aims at improving de-novo assembly in presence of a closely related reference. The idea is to combine de-novo assembly and reference guided assembly in order to obtain an enhanced assembly.","PeriodicalId":275098,"journal":{"name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"235 3 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Enhanced reference guided assembly\",\"authors\":\"F. Cattonaro, A. Policriti, F. Vezzi\",\"doi\":\"10.1109/BIBM.2010.5706540\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Next Generation Sequencing has totally changed genomics: we are able to produce huge amounts of data at an incredible low cost if compared to Sanger sequencing. Despite this some old problems have become even more difficult, denovo assembly being on top of this list. In this paper we propose a novel method that aims at improving de-novo assembly in presence of a closely related reference. The idea is to combine de-novo assembly and reference guided assembly in order to obtain an enhanced assembly.\",\"PeriodicalId\":275098,\"journal\":{\"name\":\"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"volume\":\"235 3 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BIBM.2010.5706540\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIBM.2010.5706540","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Next Generation Sequencing has totally changed genomics: we are able to produce huge amounts of data at an incredible low cost if compared to Sanger sequencing. Despite this some old problems have become even more difficult, denovo assembly being on top of this list. In this paper we propose a novel method that aims at improving de-novo assembly in presence of a closely related reference. The idea is to combine de-novo assembly and reference guided assembly in order to obtain an enhanced assembly.
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