乳腺癌治疗监测和临床结果的潜在生物标志物

Breast Cancer - Evolving Challenges and Next Frontiers Pub Date : 2021-11-24 DOI:10.5772/intechopen.100311

Yuki Yamamoto, Sabrina La Salvia, Sahoo Susmita, H. Tahara

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引用次数: 0

摘要

非编码RNA是一种不被翻译成蛋白质的RNA。这些包括转移RNA和核糖体RNA、微小RNA、转移RNA衍生片段和长链非编码RNA。已知在癌细胞或肿瘤组织中，包括microrna在内的一些非编码rna的表达水平发生改变。此外，这些非编码rna的表达谱在组织和体液之间具有相关性。因此，一些非编码rna正被用作癌症的诊断/预后生物标志物或治疗靶点。在这一章中，我们回顾了代表性的非编码rna，并特别介绍了microRNA作为诊断/预后的生物标志物和治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Potential Biomarkers for Therapeutic Monitoring and Clinical Outcome in Breast Cancer

Non-coding RNAs are a species of RNA that are not translated to proteins. These include transfer RNAs and ribosomal RNAs, microRNAs, transfer RNA-derived fragments, and long non-coding RNA. It is known that expression levels of some non-coding RNAs included microRNAs are altered in cancer cells or tumor tissues. Moreover, expression profiles of such non-coding RNAs correlate between tissues and body fluids. Therefore, several non-coding RNAs are being used as diagnostic/prognosis biomarkers or therapeutic targets in cancer. In this chapter, we review about representative non-coding RNAs and introduce especially microRNA as diagnosis/prognosis biomarkers and therapeutic targets.

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