{"title":"MTT法测定苦瓜果实的抗癌活性","authors":"R. Ahirrao","doi":"10.18689/mjim-1000120","DOIUrl":null,"url":null,"abstract":"To evaluate the anticancer activity of fruits of Momordica dioica by using MTT assay. The aqueous extract of fruits of Momordica dioica was tested against ovarian carcinoma of PA-I cell lines and human cervical cancer of Hela cell line at various concentrations. The anticancer effect of the aqueous extracts on cell inhibition was studied using MTT assay. The results showed that aqueous extract of fruits of Momordica dioica inhibited growth of PA-I and Hela cells at IC 50 concentration is 40 µg/mL respectively. Alterations in the cell morphology were also observed after treatment of the cell lines with fruit extract. The present work revealed that Momordica dioica contains some important chemical constituents extracted using aqueous as solvent that can be used further in the management of cancer treatment.","PeriodicalId":304005,"journal":{"name":"Madridge Journal of Immunology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Anticancer activity of Fruits of Momordica Dioica by using MTT assay\",\"authors\":\"R. Ahirrao\",\"doi\":\"10.18689/mjim-1000120\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To evaluate the anticancer activity of fruits of Momordica dioica by using MTT assay. The aqueous extract of fruits of Momordica dioica was tested against ovarian carcinoma of PA-I cell lines and human cervical cancer of Hela cell line at various concentrations. The anticancer effect of the aqueous extracts on cell inhibition was studied using MTT assay. The results showed that aqueous extract of fruits of Momordica dioica inhibited growth of PA-I and Hela cells at IC 50 concentration is 40 µg/mL respectively. Alterations in the cell morphology were also observed after treatment of the cell lines with fruit extract. The present work revealed that Momordica dioica contains some important chemical constituents extracted using aqueous as solvent that can be used further in the management of cancer treatment.\",\"PeriodicalId\":304005,\"journal\":{\"name\":\"Madridge Journal of Immunology\",\"volume\":\"116 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Madridge Journal of Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18689/mjim-1000120\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Madridge Journal of Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18689/mjim-1000120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Anticancer activity of Fruits of Momordica Dioica by using MTT assay
To evaluate the anticancer activity of fruits of Momordica dioica by using MTT assay. The aqueous extract of fruits of Momordica dioica was tested against ovarian carcinoma of PA-I cell lines and human cervical cancer of Hela cell line at various concentrations. The anticancer effect of the aqueous extracts on cell inhibition was studied using MTT assay. The results showed that aqueous extract of fruits of Momordica dioica inhibited growth of PA-I and Hela cells at IC 50 concentration is 40 µg/mL respectively. Alterations in the cell morphology were also observed after treatment of the cell lines with fruit extract. The present work revealed that Momordica dioica contains some important chemical constituents extracted using aqueous as solvent that can be used further in the management of cancer treatment.
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