Involvement of the intestinal microbiome in the tumor process of the gastrointestinal tract

The article assesses the degree of participation of the microbiome in the development of the pre-tumor process of the gastrointestinal tract. The necessity of studying the pathology of the gastrointestinal tract at the genetic level in relation to the persistence of microorganisms that affect the expression of human genes is shown: their proteins and metabolites interact with the genome, modifying it. The role of opportunistic microflora in the regulation of the immune response in patients with cancer and changes in microbiocenosis in lesions of the large intestine, liver and pancreas, as well as its significance in carcinogenesis are presented. The need for further studies of the mechanisms of development of the tumor process of the gastrointestinal tract and determination of the relationship between the microbiome, the human immune system and carcinogenesis is emphasized.