{"title":"苯丁酮治疗浓度对粒细胞功能的影响。","authors":"C O Solberg","doi":"10.1111/j.1699-0463.1975.tb00077.x","DOIUrl":null,"url":null,"abstract":"<p><p>The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.</p>","PeriodicalId":75410,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology","volume":"83 2","pages":"100-2"},"PeriodicalIF":0.0000,"publicationDate":"1975-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1699-0463.1975.tb00077.x","citationCount":"8","resultStr":"{\"title\":\"Influence of therapeutic concentrations of phenylbutazone on granulocyte function.\",\"authors\":\"C O Solberg\",\"doi\":\"10.1111/j.1699-0463.1975.tb00077.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.</p>\",\"PeriodicalId\":75410,\"journal\":{\"name\":\"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology\",\"volume\":\"83 2\",\"pages\":\"100-2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1699-0463.1975.tb00077.x\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/j.1699-0463.1975.tb00077.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pathologica et microbiologica Scandinavica. Section B, Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1699-0463.1975.tb00077.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of therapeutic concentrations of phenylbutazone on granulocyte function.
The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
