Evaluating the potential of Adathoda vasica against respiratory infection caused by Klebsiella pneumoniae

Adathoda vasica is the most well-known medicinal herb to treat respiratory conditions. The leaves of Adathoda vasica show a stimulant effect on the respiratory system. Adathoda vasica leaves contain rich content of alkaloids which contributes to most of the pharmacological activity. This study is aimed to evaluate the effectiveness of Adathoda vasica extract against the respiratory pathogen Klebisella pneumoniae invivo and in animal modelMethods The effectiveness of the A.vasica extract to inhibit the chief respiratory pathogen, K. pneumoniae, in vivo CFU assay was carried out in animal models The bioactive compounds were screened through GC-MS and were docked with FIMG protein and COVID 19 proteins to assess the efficacy of the compounds against respiratory infection. The result reveal A.vasica as an effective herb against respiratory infection. The ethanol extract of A.vasica was subjected to GC-MS analysis and based on the percentage of peak area, three compounds were chosen for docking analysis for FIMG and SARS-CoV-2 proteins, which revealed higher binding affinity and interacted to the residues. The grater ZOI by disc diffusion assay and reduced CFU nin plant treated rat lung tissues confirm the antibacterial potential of A.vasica against K.pneumoniae