scylliorhinin I及其Val7和Ile7类似物的合成及其GPI检测中的生物活性。

Polish journal of pharmacology and pharmacy Pub Date : 1992-01-01

K Rolka, G Kupryszewski, P Janas, J Myszor, Z S Herman

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摘要

采用固相法合成了速激肽家族的十肽丝虫草苷I及其7位含有Val或Ile的两个类似物，并对离体豚鼠回肠进行了拮抗活性测试。这两种类似物的活性都略高于scylliorhinin I，但它们的效力明显低于物质P。

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Synthesis and biological activity in the GPI test of scyliorhinin I and its Val7 and Ile7 analogs.

Scyliorhinin I, a decapeptide, of tachykinin family, and its two analogs containing Val or Ile in position 7, have been synthesized using the solid-phase method, and tested for agonistic activity on isolated guinea pig ileum. Both analogs were slightly more active than scyliorhinin I, but they were significantly less potent than substance P.

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Polish journal of pharmacology and pharmacy

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