聚合修饰对胰腺核糖核酸酶生物活性的影响。

Nauchnye doklady vysshei shkoly. Biologicheskie nauki Pub Date : 1992-01-01

N V Kalacheva, E G Kupriianov-Ashin, B M Kurpinenko

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摘要

研究了右旋糖酐修饰对胰腺RNAse药代动力学特性及其抑制细胞增殖能力的影响。研究表明，RNAse聚合物形式的生物活性的基本贡献是由偶氮键形成的，偶氮键是在蛋白质与葡聚糖支持的化学结合过程中形成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[The effect of polymeric modification on the biological activity of pancreatic ribonuclease].

The effect of modification of dextran on pharmacokinetic properties of pancreatic RNAse and on its ability to suppress the proliferation of cells has been studied. It has been shown that the basic contribution to biological activity of polymer form of RNAse is making by azo-bonds which are forming in the process of chemical bonding of the protein with dextran support.

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Nauchnye doklady vysshei shkoly. Biologicheskie nauki

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