CpG甲基化的转录抑制作用。

R Meehan, J Lewis, S Cross, X Nan, P Jeppesen, A Bird
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引用次数: 91

摘要

哺乳动物DNA甲基化与转录抑制和核酸酶抗性染色质有关。在这篇综述中,我们讨论了这些影响是如何通过结合甲基化DNA的蛋白质介导的。
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Transcriptional repression by methylation of CpG.

Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA.

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Studies of DNA methylation in animals. Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells. Analysis of the temporal program of replication initiation in yeast chromosomes. On the structure of replication and transcription factories. Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle.
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