肾上腺皮质类固醇对不同年龄大鼠肾小管转运的刺激作用。

Developmental pharmacology and therapeutics Pub Date : 1992-01-01 DOI:10.1159/000457455

H Bräunlich, H Rassbach, S Vogelsang

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引用次数: 9

摘要

强的松龙或地塞米松治疗后，对氨基马嘌呤(PAH)的肾脏排泄增加，PAH在肾皮质片中积聚，特别是在5和10日龄肾功能不成熟的大鼠中。曲安奈德对未成熟大鼠和55日龄大鼠均有效。矿化皮质激素(去氧皮质酮、醛固酮)治疗后，对多环芳烃的转运没有刺激作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Stimulation of renal tubular transport of p-aminohippurate in rats of different ages by treatment with adrenocortical steroids.

Treatment with prednisolone or dexamethasone is followed by an increase in renal excretion of p-aminohippurate (PAH) and in accumulation of PAH in renal cortical slices, particularly in 5- and 10-day-old rats with immature kidney function. Treatment with triamcinolone is effective both in immature and in 55-day-old rats. There is no stimulation of PAH transport after treatment with mineralocorticoids (desoxycorticosterone, aldosterone).

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Developmental pharmacology and therapeutics

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