白细胞介素10:综述

Progress in growth factor research Pub Date : 1992-01-01 DOI:10.1016/0955-2235(92)90020-I

Donna Rennick, Dan Berg, Gina Holland

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引用次数: 59

摘要

自白细胞介素-10的最初描述以来，有关其生物学特性的大量信息已被收集。体外研究已经迅速确定了IL-10的免疫刺激和免疫抑制活性。基于这些发现，在各种动物疾病模型中开展了体内研究，以评估这些活动的重要性。本文将对IL-10的多效性进行综述，并对IL-10调节急慢性炎症反应的研究现状进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interleukin 10: An overview

Since the original description of interleukin-10, a wealth of information concerning its biological properties has been gathered. Studies in vitro have rapidly identified both immunostimulatory and immunosuppressive activities for IL-10. Based on these findings, in vivo studies were initiated in a variety of animal disease models to assess the importance of these activities. This review will summarize the pleiotropic properties of IL-10 and will survey current research regarding the potential of IL-10 to regulate acute and chronic inflammatory reactions.

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