[某些氨基酸受体激动剂的晶格结构与生物作用的关系]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01
L S Kertser, K V Baev
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引用次数: 0

摘要

比较了甘氨酸、牛磺酸、GABA、-丙氨酸的晶体结构。用氮、氧原子间距离重合的数量和精度作为晶体结构相似性的判断标准。得出了激动剂的晶体结构与其对氨基酸受体的作用之间的关系。假设在激动剂对受体协同作用的情况下,受体表面分子的相互排列与激动剂晶体中的排列相似。
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[Relationship between the crystal lattice structure and the biological action of some agonists of amino acid receptors].

The crystal structures of glycine, taurine, GABA, beta-alanine were compared. The quantity and the accuracy of distances coincidence between nitrogen and oxygen atoms were used as a criterion of similarity of the crystalline structures. The conclusion is made about a correlation between crystalline structure of agonists and their effect on amino acid receptors. It is assumed that in case of a cooperative effect of agonist on the receptor a mutual arrangement of molecules on the receptor surface is similar to their arrangement in the agonist crystal.

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Dynamic Clamp Analysis of Synaptic Integration in Sympathetic Ganglia. [Viscerosomatic convergence on the lumbar interneurons of the dorsal horn of the spinal cord in cats and rats]. [Relationship between the crystal lattice structure and the biological action of some agonists of amino acid receptors]. [Mechanisms of calcium current decay acceleration induced by cyclic AMP]. [Influence of phosphorylation on the functional properties of the sodium channel reconstructed in an artificial membrane].
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