紫杉醇诱导的硬皮病样疾病

Sivajini Shanmugalingam, Ushagowry Saravanamuttu, Umagowry Saravanamuttu
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引用次数: 0

摘要

硬皮病样皮肤病是一种罕见的药物性皮肤病。它被归因于各种药物,最近被归因于某些肿瘤药物,特别是紫杉烷。尽管它是一种有效的化疗药物,但它会导致硬皮病样的皮肤病变,在一些患者中,如果早期发现遗漏了罪魁祸首药物,有或没有类固醇,它很少会消退。尽管其罕见的文献未经治疗的情况下发展严重的功能限制,由于皮肤纤维化。经过文献检索的探索,我们在此报告第一例紫杉醇诱导硬皮病在斯里兰卡被发现并及时治疗成功的类固醇。我们报告这个病例是为了让临床医生在遇到有化疗背景史的皮肤纤维化患者时意识到这种情况,药物诱发硬皮病的可能性。
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Docetaxal induced scleroderma like disease
Scleroderma like skin disease is a rare entity among the drug induced dermatological manifestations. It is attributed to various drugs and recently to certain oncological medications especially taxanes. Despite being an efficacious chemotherapeutic agent, it results in scleroderma like skin lesions rarely it resolves in some patients if detected early with omission of the culprit drug with or without steroids. Despite its rarity in literature untreated cases develop severe functional limitation due to skin fibrosis. After an exploration of literature search herein we report the first case of docetaxal induced scleroderma in a Sri Lankan which was detected and promptly treated with steroids successfully. We report this case to make clinicians aware about this condition when encountered with a patient having skin fibrosis with background history of chemotherapy, the possibility of a drug induced scleroderma.
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