[低剂量亚硝基甲基脲对固定细胞群的作用。一个实验和模型]。

Izvestiia Akademii nauk SSSR. Seriia biologicheskaia Pub Date : 1992-07-01

T V Krutova, S B Chernikova, A A Konradov, E B Burlakova

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引用次数: 0

摘要

研究了暴露于低剂量甲基亚硝基脲(10(-11)-10(-5)g/kg小鼠体重)后静止细胞群(小鼠脾脏)的变化，并建立了数学模型。所提出的模型是基于低剂量细胞毒素的作用具有非破坏性的“信号”特征，改变增殖区和静止区细胞之间的动态平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[The action of low doses of nitrosomethylurea on a stationary cell population. An experiment and modelling].

The change of stationary cell population (murine spleen) following an exposure to low doses of methylnitrosourea (10(-11)-10(-5) g/kg of mouse weight) was investigated and modelled mathematically. The suggested model is based on the idea that the effect of cytotoxic agent in low doses has nondestructive "signal" character, changing dynamic balance between cells in proliferating and quiescent compartments.

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Izvestiia Akademii nauk SSSR. Seriia biologicheskaia

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