{"title":"雌三醇的稳定性及与赋形剂的相容性研究","authors":"H. Canbay, M. Polat, Mahmut Doğantürk","doi":"10.30516/bilgesci.582054","DOIUrl":null,"url":null,"abstract":"Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy ( FTIR ) were used to assess the compatibility between estriol and drug excipients (1:1; w/w). In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Study of Stability and Drug-Excipient Compatibility of Estriol\",\"authors\":\"H. Canbay, M. Polat, Mahmut Doğantürk\",\"doi\":\"10.30516/bilgesci.582054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy ( FTIR ) were used to assess the compatibility between estriol and drug excipients (1:1; w/w). In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR\",\"PeriodicalId\":133012,\"journal\":{\"name\":\"Bilge International Journal of Science and Technology Research\",\"volume\":\"19 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bilge International Journal of Science and Technology Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30516/bilgesci.582054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bilge International Journal of Science and Technology Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30516/bilgesci.582054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study of Stability and Drug-Excipient Compatibility of Estriol
Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy ( FTIR ) were used to assess the compatibility between estriol and drug excipients (1:1; w/w). In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR
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