Hongfei Xu, Fei Chang, Shweta Jain, B. A. Heller, Xu Han, Yongjian Liu, R. Edwards
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SNX5 targets a monoamine transporter to the TGN for assembly into dense core vesicles by AP-3
The endosomal adaptor protein AP-3 assembles the membrane proteins of dense core vesicles (DCVs). Sorting nexin 5 targets the vesicular monoamine transporter (VMAT) to DCVs by retrograde transport from endosomes to the trans-Golgi network (TGN), thereby revealing a novel role for AP-3 at the TGN.
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