锝-t-丁基异腈(99mTc-TBI)心肌显像在冠心病中的应用

N. Nair , U.N. Nayak , P. Ramanathan , N. Ramamoorthy , S.S. Sachdeva
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摘要

99mtc -t-丁基异腈是一种有用的心肌灌注显像剂。与201 -铊相比,锝优越的物理优势使得更大剂量的成像成为可能。在心肌中的积累是单向的,一旦附着就不会离开心肌,因此需要两次单独注射来进行休息和应激成像。高肝脏摄取经常掩盖下壁,高早期摄取使得注射后立即成像几乎不可能,至少在45-60分钟内。然而,在我们的患者中,该药物被认为可以准确识别灌注不足区域并区分缺血和梗死。与201Tl和GBP区域壁面运动研究的一致性非常好。虽然其个体敏感性和特异性相当高,分别为82.6和90.9%,但在联合GBP研究中,敏感性上升至93.4%。综上所述,Tc-TBI是一种有价值的心肌灌注显像剂,特别是在像印度这样的发展中国家,Tc-MIBI由于价格昂贵而不能常规使用,而且由于进口成本高,201Tl的定期供应也不总是可行的。在这里,mtc - tbi的成本很低,而且在特定人群中,特别是在患有左前降和旋冠状动脉疾病的人群中,它可以提供有价值的信息。
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Utility of technetium-t-butyl isonitrile (99mTc-TBI) myocardial imaging in coronary artery disease
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