Effect of Curcuma Zedoaria Extract on Testis and Seminal Vesicle Weights in White Rats

Background: The participation of men in family planning, particularly in Indonesia, is still lacking. Men dislike condom and vasectomy. Therefore, experts are trying to find a safe way for men by switching modern contraceptives to plants that can inhibit spermatogenesis. Plant that has an antifertility potential is Curcuma zedoaria (Berg) Rosc. This study aimed to examine the effect of Curcuma zedoaria extract on testis and seminal vesicle weights in white rats (Rattus norvegicus). Subjects and Method: This was a completely randomized design (CRD) study with posttest only group design. A total of 24 male white rats were selected for this study and then randomized into two groups: intervention group and control group. The dependent variable was testis and seminal vesicle weights. The independent variable was Curcuma zedoaria extract. The rats in the intervention group were treated with Curcuma zedoaria extract in a dose of 300 mg/kgBW for 48 days. The data were analyzed by Independent Sample T-test. Results: Testis and seminal vesicle weights were comparable and its mean difference was statistically non-significant indicating the success of randomization. Testis and seminal vesicle weights were lower in the intervention group than in the control group, and it was statistically significant. Conclusion: The administration of Curcuma zedoaria extract can effectively reduce testis and seminal vesicle weights in male white rats.