年龄与冠状病毒感染的相关性

Faten Al-Tai, M. Al-Hamdany
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摘要

2019年全球爆发的新型冠状病毒病(COVID-19)因其迅速传播和发展而引起了全世界的关注和担忧。尽管老年患者与COVID-19相关的死亡风险较高,但很少有研究关注不同年龄组(50岁、50至60岁和60岁以上人群)COVID-19患者的临床特征和预后差异。全面的年龄评估使医生能够对所有COVID-19患者进行风险分层,无论他们身在何处,因为研究表明,该疾病的临床表现和预后在年龄组之间存在差异。与60岁以下患者相比,60岁以上患者疾病严重程度更差,临床症状更严重,病程更长。在大流行期间,公共卫生和临床专家面临的主要挑战之一是疾病严重程度的多样性。了解与COVID-19相关的年龄发病率和死亡率至关重要,因为它会影响治疗选择、预后预期和分诊。该分析的结论是,患者的临床特征和疾病预后随年龄而变化,仔细的年龄评估可以帮助世界各地的临床医生对所有COVID-19患者进行风险分层。在目前的回顾中,我们确实关注衰老与疾病概况或相关发病率之间的关系。
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The Correlation between Age and Coronavirus Infections
The global outbreak of coronavirus (COVID-19) in 2019 has attracted worldwide attention and increased concerns due to the rapid spread and progression of the disease. Despite the higher risk of death which is linked with COVID-19 in elderly patients, few studies have focused on how the clinical features and prognosis of COVID-19 patients differ between different age groups including 50 years, 50 to 60 years, and people aged above 60. A thorough assessment of age allows physicians to risk-stratify all COVID-19 patients regardless of where they are, as studies have shown that the clinical presentation and prognosis of the disease differ between age groups. Patients over 60 years of age have worse disease severity, more severe clinical symptoms and longer disease duration compared to those under 60 years of age. One of the major challenges facing public health and clinical experts during a pandemic is the diversity of disease severity. Understanding morbidity and mortality by age associated with COVID-19 is critical, as it affects treatment choices, prognostic expectations, and triage. This analysis concluded that patient clinical characteristics and disease prognosis change with age and that careful age assessment can help clinicians worldwide to risk-stratify all COVID-19 patients. In the present review, we do focus on the relationship between ageing and diseases profile or associated morbidities.
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