Research progress and prospect of circular RNA in multiple myeloma

Circular RNAs (circRNAs) are a novel type of covalently closed RNAs recently found to be involved in several physiological and pathological processes. A series of studies have proved that cyclic RNAs are related with the genesis and development of tumors, for example circ_0007841 and PVT1. Some circRNAs are strictly related to advanced clinical stage and poor prognosis, including circPTK2, circ-RNF217, circ-AFF2, circ-MYBL2, circ_0069767, circ-CDYL, circ_0000142, circRNA_101237 and exo-circMYC. In addition, circRNAs are involved in drug resistance and complications, they are circ-CCT3, Circ-007841, ciRS-7,circPVT1, circ_0001821, Exo-circ-G042080 and circCHEK1_246aa. Therefore, we propose that circRNAs can be considered as potential diagnostic and prognostic markers, which can induce chemoresistance, and might indicate novel therapeutic targets for multiple myeloma. Targeting cyclic RNA therapy will bring spring to the treatment of multiple myeloma.