Study on the treatment rules of primary epilepsy of treated by National TCM Master Yu Ying-ao

Objective: To explore and analyze the medication rule of Chinese medicine master Yu Ying-ao in the treatment of primary epilepsy, hoping to provide reference for the clinical treatment of primary epilepsy. Methods: Mining and analysis primary epilepsy Outpatient records of Chinese medicine master Yu Ying-ao, extracted the traditional Chinese medicine(TCM) diagnosis and treatment data in the medical cases, standardized the obtained TCM diagnosis and treatment data, and used the data mining function integrated by the ancient and modern medical case cloud platform V2.3.5 to carry out frequency statistics, cluster analysis, association analysis and complex network analysis on the diagnosis and treatment data, the common medicines used by Chinese medicine master Yu Ying-ao in the treatment of primary epilepsy, properties and classifications of commonly used medicines, therapeutic principle and method and coreprescriptions were obtained. Results: A total of 70 cases, 213 medical records and 231 prescriptions data of TCM were included. A total of 120 Chinese medicines were involved, and the total frequency of medication was 3388. The core prescription groups mined through the complex network method are: Raw Concha Ostreae(Shengmuli), Radix Curcumae(Yujin), Alum(Baifan), longchi, Salvia miltiorrhiza(Danshen), Caulis Bambusae in Taenia(Zhuru), Semen armeniacae amarum(Kuxingren), Semen Persicae(Taoren), Arisaema cum Bile(Dannanxing) and Amber(Hupo). In the prescription, Raw Concha Ostreae(Shengmuli) and Radix Curcumae(Yujin) were king medicines and also high-frequency medicines, all of which were cold medicines. Yu Ying-ao's clinical dosage of Alum(Baifan) was between $1.5 \sim 3\mathrm{g}$, and the curative effect was enhanced by decocting it first to remove its great fire. Yu Ying-ao's clinical high-frequency medicines are: Raw Concha Ostreae(Shengmuli), Radix Curcumae(Yujin), Alum(Baifan), Salvia miltiorrhiza(Danshen), Longchi, Semen armeniacae amarum(Kuxingren), Semen Persicae(Taoren) and Arisaema cum Bile(Dannanxing). Most of the high-frequency medicines were cold medicines (such as Shengmuli, Yujin, Baifan, Kuxingren, etc.), The specific drugs were mild cold drugs (827 times). The most common distribution of the five flavors of traditional Chinese medicine was bitter medicine (1678 times), the meridian of returning to the liver (2214 times) was the most common. The top three efficacy of 120 traditional Chinese medicines were moistening bowels (529 times), promoting blood circulation and removing blood stasis (436 times), clearing heat and resolving phlegm (385 times).Conclusion: Chinese medicine master Yu Ying-ao takes the principle of purging excess and tonifying deficiency, and purging more than tonifying. To calm the mind, invigorate the spleen, regulate the liver, moisten the internal organs, reconcile the middle, and invigorate the qi, and harmonizing lung, heart, spleen and large intestine.