Development of Rutin Ethosomes for Enhanced Skin Permeation

Materials and Methods: Rutin ethosomes using butylated hydroxytoulene (BHT) as permeation enhancer were prepared by cold method. The optimization of rutin ethosomes were done by using 23 factorial design with the help of design expert software (version 8.0). The optimized rutin ethosomes formulation were then characterized for vesicular shape, size of the particle and the size distribution by using scanning electron microscopy, zeta potential, entrapment efficiency and stability studies. The percutaneous studies of optimized rutin ethosomes with permeation enhancer were done by a specially designed franz diffusion cell by using pig ear skin and the results were studied using DD solver 8 software.