阿苯达唑中的维生素 A 对蛔虫再感染的有效性

Richo Wijaya, M. Lubis, Selfi Nafianti, I. Lubis
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引用次数: 0

摘要

世卫组织建议在 400 毫克阿苯达唑中加入 20 万国际单位的维生素 A,以减少再次感染。2016年4月至6月,一项随机对照试验在北苏门答腊省SD N 384 Sikapas进行。纳入标准为患有蛔虫病的儿童。样本分为干预组和对照组。采用卡托-卡茨法识别虫卵和粪便虫卵计数强度(FECs)。P值小于0.05为差异显著。经过三个月的随访,干预组和对照组分别有 51 和 56 个样本,平均年龄分别为 9.6 岁(SD 1.99)和 9.7 岁(SD 2.20)。蛔虫病发病率为 75.5%。干预组和对照组在蛔虫再感染方面没有明显差异,但在蛔虫感染强度方面有明显差异。NNT 为 22.31。本研究不建议在阿苯达唑中添加维生素 A。
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Effectiveness of Vitamin A in Albendazole Against Reinfection of Ascaris Lumbricoides
WHO recommends the supplementation of 200,000 IU vitamin A into 400 mg albendazole to cut down its reinfection. A Randomized Controlled Trial was conducted in SD N 384  Sikapas, North Sumatera from April - June 2016. Inclusion criteria were children with ascariasis. Sample divided into intervention and control group. Kato-Katz was used to identify egg worms and faecal egg count intensity (FECs). P value < 0.05 was consider significant. After three months follow up, there were 51 and 56 samples in intervention and control group with average age 9.6 years (SD 1.99) and 9.7 years (SD 2.20). Prevalence of ascariasis was 75.5%. There was no significant difference in Ascaris lumbricoides reinfection but instead of in FECs intensity. The NNT was 22.31. The addition of vitamin A in albendazole was not suggested according to this study.
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