一起草甘膦中毒案例

Samyogita Choudhary, Sayan Chakraborty, L. Goswami, Dhiman Sen
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引用次数: 0

摘要

草甘膦是一种市售除草剂,也是一种人体毒素。它产生广泛的临床表现,从喉咙刺激,胃肠道糜烂和出血,表面活性剂升高肝肾损伤,代谢性酸中毒,甚至死亡。我们报告一名36岁女性病例,她摄入了约400ml农药,并在摄入12小时后被送往我们的三级保健医院,处于肾功能衰竭、严重酸中毒、高钾血症和休克的状态。除了最初的复苏,我们开始进行血液灌流和CRRT。她治疗成功,出院回家了。本病例报告强调使用血液灌流除毒药筒治疗严重的草甘膦中毒,因为目前还没有已知的这种毒素的解毒剂,而且其毒性机制仍未确定。
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A case of glyphosate poisoning
Glyphosate is a commercially available herbicide which also acts as a human toxin. It produces a wide range of clinical manifestations ranging from throat irritation, GI tract erosion and bleeding, surfactant elated liver and kidney injury, metabolic acidosis and even death. We are reporting a case of a 36 year old female who consumed around 400ml of the pesticide and presented to our tertiary care hospitals after 12 hours of ingestion, in a state of renal shutdown, Severe acidosis and hyperkalemia and shock. We started on hemoperfusion and CRRT apart from the initial resuscitation. She was successfully treated and discharged home. This case report emphasise on the use of hemoperfusion toxin removing cartridge for sever glyphosate poisoning as there is no known antidote of this toxin and also the mechanism of toxicity is still not well-established?
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