用于医疗设备测试的拟人化腹主动脉瘤人工循环系统:CT扫描的三维重建

Sofia Aversa, Bilal Amin, Nuno P. Silva, M. A. Elahi
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引用次数: 0

摘要

腹主动脉瘤(AAA)是一种不可逆的腹主动脉球囊样扩张。血管内动脉瘤修复(EVAR)是AAA的主要手术治疗方法,它包括在动脉瘤内插入移植物。该手术涉及某些并发症,如移植物迁移和移植物相关的内陷。为了监测这些并发症,患者需要接受定期的随访影像学监测。研究建议通过使用长期植入式装置来监测移植物功能。该装置在EVAR手术时植入,避免了放射成像监测的需要。本研究提出了一种3d打印AAA乳胶模型和AAA模型的人工循环系统。所提出的3D模型及其人工循环系统可作为未来体外测试和优化用于evar后监测的长期植入式设备的平台。人工循环系统也可以用来显示乳胶模型对不同血流动力学条件的响应。本研究使用3D切片软件将真实患者的CT图像转换为拟人化的3D AAA模型。3D模型被打印出来制作模具。最终的乳胶模型是通过将模具浸入液体乳胶中创建的。乳胶模型与人工循环模型相连接。为了模拟人类心脏的生理参数,将脉动泵FlowTek125连接到AAA模型上。为了模拟血液的特性,将蒸馏水泵入AAA模型。该研究成功地重建了一个拟人化的AAA人工循环系统。所提出的模型可用于实验研究,特别是那些专注于开发用于evar后支架监测的新型植入式装置的实验研究。
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Anthropomorphic Abdominal Aortic Aneurysm Artificial Circulatory System for Medical Device Testing: 3D Reconstruction from CT Scans
Abdominal aortic aneurysm (AAA) is an irreversible balloon-like dilation of the abdominal aorta. Endovascular Aneurysm Repair (EVAR) is the main surgical treatment for AAA, which involves the insertion of a graft inside the aneurysm. This procedure involves certain complications such as graft migration and graft-related endoleaks. To monitor such complications patients are required to undergo regular follow-up imaging surveillance. Studies have proposed monitoring graft functioning by using a chronically implantable device. The device is implanted at the time of the EVAR surgery and avoids the need for radiological imaging surveillance. This study has proposed a 3D-printed AAA latex model and an artificial circulatory system for the AAA models. The proposed 3D model and its artificial circulatory system can be used as a platform for future in vitro testing and optimization of chronically implantable devices for post-EVAR surveillance. The artificial circulatory system can also be used to show the response of the latex model to different haemodynamic conditions. In this study, a 3D Slicer software was used to convert the Computed Tomography (CT) images of real patients into anthropomorphic 3D AAA models. The 3D models were printed to create the mould. The final latex model was created by dipping the mould in liquid latex. The latex model was connected to the artificial circulatory model. To mimic the physiological parameters of the human heart, the pulsatile pump FlowTek125 was connected to the AAA model. To mimic the properties of blood, distilled water was pumped through the AAA model. The study was successful in recreating an anthropomorphic AAA artificial circulatory system. The proposed model can be used for experimental studies, particularly those focused on developing novel implantable devices for post-EVAR stent monitoring.
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