尾侧硬膜外噻嗪或噻嗪/利多卡因联合用药对骆驼的影响及阿替帕唑的逆转作用

M. Shokry, A. Elkasapy
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引用次数: 1

摘要

8只骆驼(16例)经第一尾骨间隙行尾侧硬膜外2%噻嗪(0.15 mg/kg)或噻嗪(0.10 mg/kg) /利多卡因2% (0.22 mg/kg)联合麻醉。加入0.9% NaCl固定给药总量为5.0 ml。木嗪/利多卡因组硬膜外麻醉起效时间(98.3±1.0 min)明显快于木嗪组(71.6±1.8 min) (P0.05)。在8只骆驼(13个试验)中,评价静脉滴注阿替帕唑(5.0 μg/kg、10.0 μg/kg或15.0μg/kg)对硬膜外噻嗪或噻嗪/利多卡因镇痛的逆转作用。加入0.9% NaCl固定给药总量为5.0 ml。15.0 μg/kg的阿替帕唑是逆转镇痛作用的最佳剂量率,在几秒钟内引起明显的唤醒迹象,无任何副作用。综上所述,二甲嗪或联用利多卡因对站立位的骆驼进行尾侧硬膜外麻醉效果较好。静脉滴注阿替帕唑15.0μg/kg有效逆转尾侧诱导硬膜外麻醉。Arch Vet Sci Med 2021;[4] . DOI: 10.26502/avsm.029 .兽医科学与医学档案[j]
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Caudal Epidural Xylazineor Xylazine/Lidocainecombination in Camels (Camelus Dromedarius) and its Reversal by Atipamezole
Caudal epidural xylazine 2% (0.15 mg/kg) or xylazine (0.10 mg/kg) /lidocaine 2% (0.22 mg/kg) combination anesthesia through the first intercoccygeal space was evaluated in 8 camels (16 trials). The total volume administered was fixed at 5.0 ml by adding 0.9% NaCl. The onset of epidural anesthesia was significantly faster (P<0.05) with xylazine/lidocaine (3.5 ± 0.4 minutes) than with xylazine (8.4 ± 0.4 minutes) while the duration was significantly longer ( P>0.05) with xylazine/lidocaine (98.3 ± 1.0 minutes) than with xylazine (71.6 ± 1.8 minutes). The reversal of epidural xylazine or xylazine/lidocaine inducedanalgesia with IV atipamezole at (5.0 μg/kg, 10.0 μg/kg or 15.0μg/kg) was evaluated in 8 camels (13 trials). The total volume administered was fixed at 5.0 ml by adding 0.9% NaCl. Atipamezole at 15.0 μg/kg was the optimum dose rate for reversing the analgesic effect and provoked marked signs of arousal within few seconds without any side effects. We can concluded that caudal epidural anesthesia was easily performed in camels in standing position with xylazine or its combination with lidocaine. IV atipamezole at 15.0μg/kg for effectively reversing the induced caudal epidural anesthesia. Arch Vet Sci Med 2021; 4 (4):103-110 DOI: 10.26502/avsm.029 Archives of Veterinary Science and Medicine 104
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