[超级致癌物和超级诱变剂——亚硝基烷氧烷基胺——氮氧化物的有效生产者]。

A F Vanin, Iu P Vedernikov, M E Galagan, S M Ignatov, L N Kubrina, I V Malenkova, P I Mordvintsev, R G Kostianovskiĭ
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引用次数: 0

摘要

亚硝基氧烷基胺在体内比亚硝基烷基胺更有效地产生氮氧化物。用EPR法监测氮氧化物的生成。研究了脱硝基化的模式。所研究的化合物在体内产生氮氧化物的能力可能与其致癌和致突变作用有关。
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[Supercarcinogens and supermutagens--nitrosoalkoxyalkylamines--effective producers of nitrogen oxide].

Nitrosoalcoxyalkylamines are more efficient producers of nitrogen oxide in vivo than nitrosoalkylamines. Production of nitrogen oxide was monitored by EPR. The patterns of denitrosylation have been studied. The ability of the studied compounds to produce nitrogen oxide in vivo may be related to their carcinogenic and mutagenic action.

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