Evaluation of Thrombolytic Potential of Elaeagnus rhamnoides (L.) A. Nelson

Plants find a special significance in the field of medicine due to their therapeutic value. Thrombolytic agents play a crucial role in the treatment of numerous human diseases including atherothrombotic diseases, pulmonary embolism, and myocardial infarction. The current study  was performed to evaluate the thrombolytic potential of Elaeagnus rhamnoides (L.) A. Nelson (Sea buckthorn or SBT). The extract of leaves, stems, and berries of the investigated plant displayed 28%, 26%, and 44% blood clot lysis, respectively as compared to that of a standard thrombolytic agent namely streptokinase (59% lysis). The fruit extract of sea buckthorn was found to display higher thrombolytic potential as compared to that of its leaves and stem. It was concluded that the extract of leaves, stem, and berries  of SBT may find applications  in the future as a thrombolytic agent. The presence of important functional groups  for instance, alcohol, aldehyde, alkyne, alkene, amines, and ester in different ariel parts of  SBTwere verified by FTIR spectroscopy.