POTENSI KOMBINASI EKSTRAK Halimeda sp. DAN SAMBILOTO SEBAGAI IMUNOSTIMULATOR BAGI LANSIA DARI PAPARAN COVID-19

The COVID-19 pandemic is causing a significant public health crisis. The elderly who are old and usually have a weak immune system can be fatal if exposed to the Covid-19 virus. One of the efforts that can be done so that the elderly are prevented from exposure to COVID-19 is by protecting them from within the body by having a strong immune system—increasing immunity in the elderly by consuming foods with high antioxidant compounds, including the algae Halimeda sp and Sambiloto. This study aims to determine the characteristics and potency of Halimeda sp. and bitter combination compound to increase body immunity using in silico analysis. The best total phenol and IC50 values were obtained from the 1:1 weight ratio treatment between the crude extract of Halimeda sp algae and the crude extract of bitter leaf. GC-MS analysis with screening quality above 85% obtained 3 (three) compounds, namely 2-Butoxyethanol (74.12%), gamma-Butyrolactone (23.72%), and Phenol (2.15%). These compounds have potential as antioxidants, anti-inflammatory, immunostimulators, and antivirals based on the PASS server. All compounds have good drug-likeness potential, absorption, distribution, metabolism, excretion, and toxicity in the body based on in silico analysis (SwissADME and Pro Tox II). It can be the basis for developing nutraceuticals for the elderly to increase immunity and prevent exposure to Covid-19.