c-myc蛋白在伯基特淋巴瘤和ebv转化淋巴母细胞样细胞系中的差异表达

Anders D. Wennborg , Ender Altiok , John P. Moore , Ingemar Ernberg , George Klein
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引用次数: 8

摘要

用ELISA法检测了eb病毒(EBV)转化的3种人b细胞衍生系中c-myc蛋白的表达水平。比较了6个独立维持的相同ebv转化的前b细胞系(FLEB-14)、6个b细胞系(LCL)和6个伯基特淋巴瘤细胞系(BL)的亚系。c-myc蛋白的平均含量在三组之间有所不同,这是根据每系至少三个独立的测试计算出来的。以相对单位表示,LCL:FLEB:BL系的均值之比为1:2:5。P <差异有统计学意义;0.01.
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Differential c-myc protein expression in Burkitt's lymphomas and EBV-transformed lymphoblastoid lines

The levels of c-myc protein expression in three types of Epstein-Barr virus (EBV) transformed human B-cell derived lines were examined with an ELISA assay. Six independently maintained sublines of the same EBV-transformed pro-B-cell line (FLEB-14), six B-cell lines (LCL) and six Burkitt's lymphoma lines (BL) were compared. The average amount of c-myc protein, calculated from at least three independent tests on each line, differed between the three groups. Expressed in relative units, the ratio of the means was 1:2:5 for the LCL:FLEB:BL lines. The differences were statistically significant at P < 0.01.

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