脐带挤奶对足月和早产儿预后的评价,对照临床试验

O. Taha
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摘要

早期可能导致婴儿贫血,因此它可以剥夺婴儿60至100毫升全血,代表30-50毫克/公斤的铁。脐带挤奶是一种安全的技术。研究目的:本研究的目的是评估脐带挤奶与早期脐带夹紧对足月和近足月新生儿血液学参数(血红蛋白、堆积细胞体积、胆红素和铁蛋白)的影响。材料与方法:本研究采用随机对照临床试验。研究对象随机分为两组(200例新生儿在距脐带25 cm处剪断并夹住脐带进行挤奶)和200例新生儿早期脐带夹住而不挤奶作为对照组),均为足月和近月儿。结果:研究组在出生12、48小时和6周时血红蛋白水平(16.9、16.9和15.5 gm/dl)较对照组(16.2、16.2和15.0 gm/dl)显著升高;研究组在出生6周时血清铁蛋白水平(135.4 μg/ml)较对照组(128.8 μg/ml)显著升高。研究组出生后12、48小时的红细胞压积水平显著高于对照组(p= 0.016)。研究组患者血清胆红素略有升高,但无患儿需要光疗。结论:脐带挤奶可改善足月和近足月新生儿的血红蛋白和铁状态。
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Assessment of Umbilical Cord Milking on the Outcome of Term and Preterm Infants, Controlled Clinical Trial
Early may contribute to anemia in infancy thus it can deprive the infant of 60 to 100 ml of whole blood representing 30-50 mg/kg of iron. The umbilical cord milking is a safe technique. Aim of the study: The aim of the study to assess the effects of umbilical cord milking as compared with early cord clamping on hematological parameters (hemoglobin, packed cell volume, bilirubin and ferritin) among term and near term neonates. Materials & methods: This study was carried out as randomized, controlled clinical trial. The subjects were divided randomly into two groups (200 neonates who the cord was milked after cutting and clamping at 25 cm from the umbilicus as a study group and 200 neonates who were received early cord clamping without milking as a control group) in term and near term infants. Results: the hemoglobin level significantly increased in study group at 12, 48 hours and 6 weeks of birth (16.9, 16.9 &15.5 gm/dl) as compared with control group (16.2, 16.2 &15.0 gm/dl) and serum ferritin level significantly increased in study group at 6 weeks of birth (135.4 μg/ml) as compared with control group (128.8 μg/ml). The hematocrit level at 12 and 48 hours after birth was significantly higher in study group (p= 0.016). Serum bilirubin was slightly elevated in study group but there were not any infants of them needed phototherapy. Conclusions: Umbilical cord milking improved hemoglobin and iron status in term and near term neonates.
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