E. Lambert, Elodie Barthout, R. Manczak, S. Saada, Lea Ikhlef, R. Formento, M. Verdier, C. Dalmay, B. Bessette, F. Lalloué, A. Pothier
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Biological Cell Characterization and Discrimination Based on UHF-Dielectrophoresis for Next Generation of Liquid Biopsy Analysis
This paper introduces results about characterizations of different tumor cell lines, using intracellular sensing based on Ultra High Frequency dielectrophoresis (UHF-DEP). Above 50 MHz, presented technic allows to probe internal cell content to characterize its cytoplasm permittivity and conductivity properties. The measured frequency-dependent cell behavior results on a distinctive DEP signature according to the cell type and its biological specificity. This paper illustrates the high potential of UHF lab-on-chip sensor to discriminate various tumor cell types derived from different tissues.